Luprodex 3M Injection

What is Luprodex 3M Injection?

Luprodex 3M is a leuprolide acetate injection. It belongs to a category of medicines called gonadotropin-releasing hormone (GnRH) medicine. It is widely used in the treatment of prostate cancer in men. Prostate cancer is cancer of the prostate gland (a small gland under the bladder that produces semen) found only in men. The symptoms include difficulty in urination, pain, numbness, or sexual problems. Also used to treat hormone-responsive breast Cancer, uterine fibroids (non-cancerous growths of the uterus Endometriosis. Endometriosis is a painful illness in which the tissue that normally lines the inside of the uterus grows outside of your uterus.

What does Luprodex 3M injection do?

Luprodex 3M Injection reduces the number of sex hormones (testosterone in men and estrogen in women). Decreasing the testosterone levels in the blood levels in males. The injection acts by shutting off hormones made by the ovaries (female reproductive organs), so the estrogen (one of the hormones that causes females to have periods) level is lowered. Also used in the treatment of central precocious puberty, in which a child’s body begins to change into an adult too soon, caused by a release of certain hormones.

Uses of Leuprolide Acetate 11.25 mg injection

• Prostate cancer: Slows tumor growth by reducing testosterone levels
• Endometriosis: Relieves pelvic pain and slows tissue growth
• Uterine fibroids: Shrinks fibroids and reduces bleeding before surgery
• Delays in early puberty in children
• Controls ovulation timing during fertility treatment (lower doses are usually used)

How It Works

• Leuprolide initially stimulates GnRH receptors, causing a short-term hormone surge
• With continued use, it desensitizes these receptors
• This leads to a drop in LH and FSH levels
• As a result, it lowers estrogen in women and testosterone in men
• This hormonal suppression helps manage conditions that depend on these hormones.
• Leading to a decrease in cancer cell growth when treating male patients and decreasing the growth rate in kids.

Use of Luprodex 3M injection in paediatrics?

Leuprolide acetate is primarily used in children to treat:

• It treats a rare condition where puberty starts too early (before age 8 in girls, 9 in boys).
• It helps in slowing down early sexual development by suppressing the pituitary gland’s release of LH and FSH hormones.
• This helps delay physical signs of puberty, allowing more time for normal growth and development.

It’s usually given as a monthly or 3-monthly injection and is discontinued once the child reaches an appropriate age for puberty to proceed naturally

Side effects

There are some common side effects in men of this injection like tiredness, decreased interest in sex, vaginal dryness, headache, changes in breast size, breast pain & tenderness, and difficulty in sleeping & there are some side effects noticed in children like acne,  mood swings, pain, rashes,  swelling and irritation at the injectable area, vaginal bleeding.

Other information

Before taking this injection, inform your doctor if you have any allergic reactions to any other medicines. And if you are a pregnant or breastfeeding mother. & if you have abnormal vaginal bleeding, depression, a blood disorder, osteoporosis, spinal cord injury, and if earlier you suffer from heart disease or brain tumor.

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