Palnat 125 mg capsule

What is Palnat 125 mg capsule?

Palnat 125 mg is an oral anti‑cancer capsule. It helps treat certain breast cancer. Containing the active ingredient Palbociclib. It treats hormone receptor-positive (HR+) and HER2-negative advanced or metastatic breast cancer. The doctor gives it together with hormonal therapy like letrozole, anastrozole, which are aromatase inhibitors, in the initial phase or with fulvestrant injection. When given in combination, it reduces cancer cell growth.

How it works?

Cancer cells keep dividing without brakes. For division, they pass a gate called G1 to S phase. Two proteins CDK4 and CDK6 push the cell through this gate by phosphorylating Rb protein. Palnat 125 mg blocks CDK4/6. The gate stays closed. Cell stuck. Many cancer cells then age and die. Healthy normal cells feel less effect because they divide slower.

When it is prescribed?

• Post‑menopausal women with HR+/HER2‑ metastatic breast cancer as first line with letrozole treatment.
• Premenopausal women also, but the doctor adds ovarian suppression (like goserelin).
• After previous hormonal therapy failed, used with fulvestrant.

Dose & Schedule

• Standard starting dose: 125 mg once daily.
• Take 21 days continuously, then 7 days break. This is one 28‑day cycle.
• Swallow whole with food (light meal best). Same time each day.
• Do not crush or open the capsule.

Get a regular CBC (complete blood count) test done.

Missed dose?

If you miss and still within 12 hours of your usual time, take it now. If more than 12 hours, just skip. Do not double. If you vomit after taking it, do not re‑dose that day. Continue the next day’s schedule. Ask your doctor for more clarity about your dosage.

How to store?

• Store it in a cool and dry place.
• Keep it in its original bottle.
• Do not take the capsule out of the bottle unless you have to take your medicine.

Common side effects

• low white cells. You usually cannot feel it. Need a blood test.
• Leukopenia, anemia
• Lowered platelet count
• Tiredness, weakness
• Loss of appetite is mild
• Nausea, soft stool, or mild diarrhoea.
• Mouth sores
• Mild hair thinning (usually partial, not full bald like some other chemo).
• Mild rash.
• Joint or muscle ache.
• Slight increase in liver enzymes.
• fever ≥38°C
• Lung inflammation
• Serious infection (pneumonia, sepsis).

Other information

• Wash hands often; low neutrophils raise infection risk.
• Avoid crowded cough places during low-count days (mid-cycle).
• A balanced protein protein-rich diet keeps strength. Small, frequent meals for nausea.
• Gentle exercise (short walk) lifts energy, but rest when the body asks.
• Use a soft toothbrush and, electric razor to reduce bleeding risk if the platelets are low.
• Rinse your mouth with bland saline or baking soda solution to prevent mouth sores.
• Keep a small symptom diary; note day of cycle so doctor sees pattern (e.g., fatigue peaks day 18).
• Do not start new over‑the‑counter or herbal medicines without confirming with your doctor.
• When the white blood cell count is <1000 or the platelet < 50,000, your doctor may stop the medication temporarily till you recover, then restart lower.
• Severe mouth sores or lung inflammation suspicion: interrupt.

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